Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 380, Issue 16, Pages 1582-1584Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc1801927
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Funding
- Division of Intramural Research of the National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurologic Disorders and Stroke
- Clinical Center of the National Institutes of Health
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIAHG200372] Funding Source: NIH RePORTER
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The manifestations of a deficiency of adenosine deaminase 2, a genetic disease, include early-onset lacunar stroke. In a series of 15 patients with this disorder, treatment with a TNF inhibitor resulted in a reduction from 37 strokes to no strokes during 733 patient-months.
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