4.8 Letter

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease

Journal

NEW ENGLAND JOURNAL OF MEDICINE
Volume 380, Issue 15, Pages 1483-1485

Publisher

MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc1813435

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Funding

  1. Janssen Research and Development

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A preliminary analysis of a trial involving participants with brain amyloid deposition who are at risk for dementia due to Alzheimer's disease showed no benefit of a beta-secretase enzyme inhibitor over placebo and a potential signal of worse cognitive test scores over 3 and 6 months.

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