Journal
NEUROSCIENCE
Volume 410, Issue -, Pages 264-273Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2019.05.018
Keywords
neurobrucellosis; neuroinflammation; glial activation; neurotoxicity; blood brain barrier
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Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCYT-Argentina) [PICT 2014-1111, 2014-1925, 2015-0316, 2016-1493, 2017-1393, 2017-1905]
- CONICET (Argentina) [PIP 0200]
- UBACYT from University of Buenos Aires (Argentina) [20020170100320BA]
- CONICET (Argentina)
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Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
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