Journal
BIOMACROMOLECULES
Volume 16, Issue 5, Pages 1614-1621Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b00190
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Funding
- BBSRC
- MRC
- Wellcome Trust
- Leverhulme Trust
- Cambridge Nanoscience Centre
- Unilever
- Kings College London
- Biotechnology and Biological Sciences Research Council [BB/J014346/1] Funding Source: researchfish
- BBSRC [BB/J014346/1] Funding Source: UKRI
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Starch is a prominent component of the human,diet and is hydrolyzed by alpha-amylase post ingestion Probing the mecharnsni of this process has proven challenging, due to the intrinsic,heterogeneity of individual starch granules By means of solution-state NMR, we demonstrate that flexible polysaccharide chains protruding from the solvent exposed surfaces of waxy rice starch granules are highly mobile and that during hydrothermal-treatment, when the granules swell; the number of flexible residues on the exposed surfaces ineteases by a factor of 15. Moreover, we show that these flexible chains are the primary substrates for a-amylase, being cleaved in the initial stages of hydrolysis. These findings allow us to conclude that the quantity of flexible a-glucan chains protruding from the granule surface will greatly influence the rate of energy acquisition from digestion of starch.
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