Journal
NEUROBIOLOGY OF AGING
Volume 81, Issue -, Pages 58-66Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2019.05.007
Keywords
Dementia; Hippocampal shape; Hippocampal texture; Prediction; MRI; Population-based
Categories
Funding
- Netherlands Organisation for Scientific Research NWO
- Danish National Advanced Technology Foundation [034-2011-5]
- Eurostars [8234]
Ask authors/readers for more resources
Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value extends to cognitively healthy individuals. Using 510 subjects from the Rotterdam Study, a prospective, population-based cohort study, we investigated if hippocampal volume, shape, texture, and their combination were predictive of dementia and determined how predictive performance varied with time to diagnosis and presence of early clinical symptoms of dementia. All features showed significant predictive performance with the area under the receiver operating characteristic curve ranging from 0.700 for texture alone to 0.788 for the combination of volume and texture. Although predictive performance extended to those without objective cognitive complaints or mild cognitive impairment, performance decreased with increasing follow-up time. We conclude that a combination of multiple hippocampal features on magnetic resonance imaging performs better in predicting dementia in the general population than any feature by itself. (C) 2019 The Author(s). Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available