Journal
NEUROBIOLOGY OF AGING
Volume 89, Issue -, Pages 132-141Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2019.02.030
Keywords
White matter hyperintensity; Hippocampal loss; Physical activity; Intervention; Cognitive impairment
Categories
Funding
- Australia's National Health and Medical Research Council [1005492]
- CSIRO Flagship Collaboration Fund
- Science and Industry Endowment Fund (SIEF)
- Edith Cowan University (ECU)
- Alzheimer's Australia (AA)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd
- Hollywood Private Hospital
- Sir Charles Gardner Hospital
- National Health and Medical Research Council
- Dementia Collaborative Research Centres program (DCRC2)
- McCusker Alzheimer's Research Foundation
- Government of Victoria
- Mental Health Research institute (MHRI)
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White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure WMH or the secondary outcome measure hippocampal volume. In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss. (C) 2019 Elsevier Inc. All rights reserved.
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