Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 26, Issue 5, Pages 335-336Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-019-0215-0
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Funding
- NCI NIH HHS [R01 CA225637] Funding Source: Medline
- NIGMS NIH HHS [R15 GM114713] Funding Source: Medline
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Ribonucleotides that are misincorporated into DNA during replication are removed by topoisomerase 1, which generates 3'-terminal adducts that are not amenable to DNA repair and thus compromise genome stability. A recent report by Li et al. reveals that Apn2/APE2 resolves such blocked 3' termini, thereby suppressing topoisomerase 1-induced mutations at ribonucleotide monophosphate sites within the genome.
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