Computational time-of-flight diffuse optical tomography

Imaging through a strongly diffusive medium remains an outstanding challenge, in particular in applications in biological and medical imaging. Here, we propose a method based on a single-photon time-of-flight camera that allows, in combination with computational processing of the spatial and full temporal photon distribution data, imaging of an object embedded inside a strongly diffusive medium over more than 80 transport mean free paths. The technique is contactless and requires I s acquisition times, thus allowing Hz frame rate imaging. The imaging depth corresponds to several centimetres of human tissue and allows us to perform deep-body imaging as a proof of principle.