Journal
NATURE CHEMICAL BIOLOGY
Volume 15, Issue 6, Pages 556-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-019-0277-7
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Funding
- National Health and Medical Research Council of Australia [1138466, 1071659, 1141131, 1086786]
- Australian Research Council [FT130100361]
- Institute for Molecular Bioscience (Research Advancement Award)
- University of Queensland
- Australian Research Council [FT130100361] Funding Source: Australian Research Council
- National Health and Medical Research Council of Australia [1086786] Funding Source: NHMRC
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Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation.
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