Journal
NATURE CELL BIOLOGY
Volume 21, Issue 5, Pages 542-551Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-019-0311-8
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Funding
- Ministry of Science and Technology of China [2016YFA0100701]
- Chinese Academy of Sciences [XDB19020104]
- National Natural Science Foundation of China [31830108, 31821004, 31725009, 31861143025]
- Howard Hughes Medical Institute [55008728]
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A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.
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