Journal
NATURE BIOTECHNOLOGY
Volume 37, Issue 5, Pages 527-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41587-019-0070-x
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Funding
- IWT-innovation fellowship [IM-140851]
- AVEVE Biochem, AVEVE Group
- Research Foundation Flanders (FWO project) [G0C9714N]
- European Research Council [ERC-2013-CoG-616966]
- Ghent University
- VIB
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Oral antibodies that interfere with gastrointestinal targets and can be manufactured at scale are needed. Here we show that a single-gene-encoded monomeric immunoglobulin A (IgA)-like antibody, composed of camelid variable single domain antibodies (VHH) fused to IgA Fc (mVHH-IgA), prevents infection by enterotoxigenic Escherichia coli (F4-ETEC) in piglets. The mVHH-IgA can be produced in soybean seeds or secreted from the yeast Pichia pastoris, freeze- or spray-dried and orally delivered within food.
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