Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino

Two new physalin derivatives named 7 beta-ethoxyl-isophysalin C (1) and 3 beta-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B (2) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds 1 and 2 were tested for their cytotoxicity against PC-3 cancer cell lines. Compound 1 showed apparent moderate with IC50 values of 8.26 mu M, whereas compound 2 exhibited no cytotoxicity against PC-3 cancer cell lines. [GRAPHICS] .

Automated summary

Two new physalin derivatives were isolated from Physalis alkekengi. Compound 1 exhibited moderate cytotoxicity against PC-3 cancer cells, while compound 2 showed no cytotoxicity.