Journal
NATURAL PRODUCT RESEARCH
Volume 34, Issue 21, Pages 3027-3035Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1607331
Keywords
Euphorbia fischeriana Steud; highly oxygenated abietanes; phorbol esters; lysosomal biogenesis
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Funding
- National Science Foundation of China [21432010]
- Technological leading talent project of Yunnan [2015HA020]
- Youth Innovation Promotion Association of CAS [2015323]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province
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Twenty-two diterpenoids (1-22), including two new ones (1, a tigliane-type diterpenoid and 8, an abietane-type diterpenoid) were isolated from the roots of Euphorbia fischeriana Steud. Among them, compounds 4, 7, 12, 14-16, 19-21 are isolated from this plant for the first time. Their structures were elucidated through extensive 1D, 2D NMR and the HRESIMS data. The C-13 data of 4 is hereby presented for the first time. The macrocyclic diterpenes 1 and 2 showed marked enhancement of lysosomal biosynthesis after evaluation using lysoTracker staining method. [GRAPHICS] .
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