Journal
NANOTECHNOLOGY
Volume 30, Issue 35, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/ab209d
Keywords
mesoporous silica; ethane-bridged nanoparticles; thermal/pH sensitivity; drug delivery; two silicon source
Funding
- project of Science and Technology Innovation Team of Outstanding Young and Middle-aged Scientists, Department of Education of Hubei Province, China [T201801]
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The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m(2) g(-1), 3.7 nm, 0.58 cm(3) g(-1), respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA-MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA-MSNs demonstrated high drug encapsulation efficiency (70.4% +/- 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.
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