Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 17, Issue -, Pages 359-379Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2019.01.016
Keywords
Brain pathology; Nanomedicine; Neuropharmacology; Blood brain bather; Extracellular matrix
Funding
- ERA. NET Rus Plus grant (NABUCO) [169]
- DFG [SA 433/28-1]
- Special Research Account of University of Crete [4602, 4920, 3963]
- PATHDERM [PN-III-P1-1.2-PCCDI-2017-0341]
- REGMED [PN-III-P1-1.2-PCCDI-2017-0782]
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Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies need to address the important hurdle of NP passage across the BBB as well as the altered cellular up-take due to the pathophysiological changes of the damaged or diseased tissue as well as immunological and toxicological aspects of nanomedicine penetration. This review therefore scopes to: 1) outline the state-of-the art knowledge on BBB passage, 2) address the significant influence of pathological conditions on nanoparticulate drug delivery, and, 3) highlight the largely neglected role of the extracellular matrix (ECM). Interactions of the nanosystem with biological barriers, cells and ECM in the milieu of brain pathologies are critically discussed in order to present a holistic overview of the advances and pits of nanomedicine applications in brain disease. (C) 2019 Elsevier Inc. All rights reserved.
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