Journal
MOLECULES
Volume 24, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules24101950
Keywords
quorum sensing; fungi; quorum-sensing molecules; quorum-sensing inhibitors; antifungal activity
Funding
- National Natural Science Foundation of China (NSFC) [31571801, 31871772]
- Beijing Natural Science Foundation [6192003]
- BTBU Basic Scientific Research Operating Fee in 2019 [PXM2019-014213-000007]
- Talent Training Quality Construction-First Class Professional Construction [PXM2019-014213-000010]
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The theory of persisting independent and isolated regarding microorganisms is no longer accepted. To survive and reproduce they have developed several communication platforms within the cells which facilitates them to adapt the surrounding environmental changes. This cell-to-cell communication is termed as quorum sensing; it relies upon the cell density and can stimulate several traits of microbes including biofilm formation, competence, and virulence factors secretion. Initially, this sophisticated mode of communication was discovered in bacteria; later, it was also confirmed in eukaryotes (fungi). As a consequence, many quorum-sensing molecules and inhibitors have been identified and characterized in various fungal species. In this review article, we will primarily focus on fungal quorum-sensing molecules and the production of inhibitors from fungal species with potential applications for combating fungal infections.
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