4.6 Article

General, Practical and Selective Oxidation Protocol for CF3S into CF3S(O) Group

Journal

MOLECULES
Volume 24, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/molecules24071249

Keywords

trifluoromethylsulfides; trifluoromethylsulfoxides; oxidation; trifluoroperacetic acid; dihydrogen peroxide

Funding

  1. CNRS

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A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H2O2 aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.

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