Journal
MOLECULES
Volume 24, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules24091686
Keywords
marine fungus; Penicillium sp; penixanthone; macrodiolide; chromone
Funding
- National Natural Science Foundation of China [21772210, 41776169]
- Guangzhou Science and Technology Project [201804010462]
- Natural Science Foundation of Guangdong Province [2018A0303130219]
- Scientific Research Projects of Hubei education department for Young Scholars [Q20171109]
- Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDME-2018C010]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09735001-002-003]
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A new macrodiolide, mangrovlide A (1) and two new polycyclic chromones, penixanthones C (2) and D (3), as well as four other known compounds (4-7), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSIO041218, cultured in the 0.25% NaCl rice substrate. The structures of the new compounds were determined by analysis of the NMR and MS spectroscopic data. Compound 1 possesses a 10-membered macrodiolide unit, while 2 and 3 are chromones with an unprecedented 6/6/6/5 polycyclic skeleton. Compounds 1-7 were evaluated for their cytotoxicities, while all the compounds displayed weak or no activity.
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