Journal
MOLECULAR PHARMACEUTICS
Volume 16, Issue 7, Pages 3109-3120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.9b00342
Keywords
atherosclerosis; neutrophil; inflammation; cellular vehicles; targeting delivery
Funding
- National Natural Science Foundation of China [81773664, 81473153, 81503006]
- Natural Science Foundation of Jiangsu Province [BK20150698]
- National Basic Research Program of China [2015CB755504]
- 111 Project from the Ministry of Education of China
- State Administration of Foreign Expert Affairs of China [111-2-07, B17047]
- Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX201811]
- Opening Project of Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (Sichuan University)
- Double First-Class University project [CPU2018GF10]
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Given the multiple interactions between neutrophils (NEs) and atherosclerosis (AS), in this study, we exploited NEs as cellular vehicles loaded with cationic liposomes for actively targeting atherosclerotic sites. The cellular vehicles based on NEs possess efficient internalization of cationic liposomes and sensitive response to the chemotaxis of atherosclerotic inflammatory cells, which ultimately realize the targeted delivery of the cargos into the target cells in vitro. Moreover, these effects also translated to significant enhancement of the accumulation of NEs' cargos into the atherosclerotic plaque in vivo after administering NE vehicles to the AS animal model. Consequently, cellular vehicles based on NEs could be a novel strategy for targeted delivery of payloads into atherosclerotic plaque, which would facilitate theranostics for AS and the development of anti-AS drugs to manage the disease.
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