Oxidative CaMKII as a potential target for inflammatory disease

CaMKII is a calcium-activated kinase, proved to be modulated by oxidation. Currently, the oxidative activation of CaMKII exists in several models of asthma, chronic rhinosinusitis with nasal polyps, cardiovascular disease, diabetes mellitus, acute ischemic stroke and cancer. Oxidized CaMKII (ox-CaMKII) may be important in several of these diseases. The present review examines the mechanism underlying the oxidative activation of CaMKII and summarizes the current findings associated with the function of ox-CaMKII in inflammatory diseases. Taken together, the findings of this review aim to improve current understanding of the function of ox-CaMKII and provide novel insights for future research.