Journal
MOLECULAR CANCER
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-019-0980-8
Keywords
Extracellular vesicles; Tumor microenvironment; Cancer biology; Therapeutic target; Clinical biomarker
Categories
Funding
- National Key Research and Development Program of China [2016YFC1302400]
- National Natural Science Foundation of China (NSFC) [81472709, 31671425, 31871380]
- Key Lab of Stem Cell Biology of Chinese Academy of Sciences
- National 1000 Young Talents Research Program of China
- U.S. Department of Defense (DoD) Prostate Cancer Research Program (PCRP) (Idea Development Award) [PC111703]
- CRUK [A12011]
- Breast Cancer Now [2012MayPR070, 2012NovPhD016]
- Medical Research Council of the United Kingdom [MR/N012097/1]
- Cancer Research UK Imperial Centre
- NIHR Imperial BRC
- Imperial ECMC
- MRC [MR/N012097/1] Funding Source: UKRI
Ask authors/readers for more resources
Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. Increasing lines of research advances have revealed the critical role of EVs in the establishment and maintenance of the tumor microenvironment (TME), including sustaining cell proliferation, evading growth suppression, resisting cell death, acquiring genomic instability and reprogramming stromal cell lineages, together contributing to the generation of a functionally remodeled TME. In this article, we present updates on major topics that document how EVs are implicated in proliferative expansion of cancer cells, promotion of drug resistance, reprogramming of metabolic activity, enhancement of metastatic potential, induction of angiogenesis, and escape from immune surveillance. Appropriate and insightful understanding of EVs and their contribution to cancer progression can lead to new avenues in the prevention, diagnosis and treatment of human malignancies in future medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available