Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 486, Issue -, Pages 89-95Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2019.02.019
Keywords
GPCR; Dimerization; Allostery; Class C GPCRs
Categories
Funding
- CNRS
- Inserm
- university of Montpellier
- Agence Nationale de la Recherche [ANR-12-BSV2-0015]
- foundation pour la Recherche Medicale [DEQ20130326522, DEQ20170336747]
- CisBio bioassays
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV2-0015] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
For more than twenty years now, GPCR dimers and larger oligomers have been the subject of intense debates. Evidence for a role of such complexes in receptor trafficking to and from the plasma membrane have been provided. However, one main issue is of course to determine whether or not such a phenomenon can be responsible for an allosteric and reciprocal control (allosteric control) of the subunits. Such a possibility would indeed add to the possible ways a cell integrates various signals targeting GPCRs. Among the large GPCR family, the class C receptors that include mGlu and GABA(B) receptors, represent excellent models to examine such a possibility as they are mandatory dimers. In the present review, we will report on the observed allosteric interaction between the subunits of class C GPCRs, both mGluRs and GABA(B)Rs, and on the structural bases of these interactions. We will then discuss these findings for other GPCR types such as the rhodopsin-like class A receptors. We will show that many of the observations made with class C receptors have also been reported with class A receptors, suggesting that the mechanisms involved in the allosteric control between subunits in GPCR dimers may not be unique to class C GPCRs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available