Journal
MICROBIOLOGY-SGM
Volume 165, Issue 10, Pages 1041-1060Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000807
Keywords
regulatory networks; iron; yeast; evolution
Categories
Funding
- Agence Nationale pour la Recherche (CANDIHUB project) [ANR-14-CE14-0018-02]
- 'Complexite du vivant' doctoral school
- Agence Nationale pour la Recherche (STRUDYEV project) [ANR-10-JCJC-1603]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0018, ANR-10-JCJC-1603] Funding Source: Agence Nationale de la Recherche (ANR)
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Iron is an essential element to most microorganisms, yet an excess of iron is toxic. Hence, living cells have to maintain a tight balance between iron uptake and iron consumption and storage. The control of intracellular iron concentrations is particularly challenging for pathogens because mammalian organisms have evolved sophisticated high-affinity systems to sequester iron from microbes and because iron availability fluctuates among the different host niches. In this review, we present the current understanding of iron homeostasis and its regulation in the fungal pathogen Candida glabrata. This yeast is an emerging pathogen which has become the second leading cause of candidemia, a life-threatening invasive mycosis. C. glabrata is relatively poorly studied compared to the closely related model yeast Saccharomyces cerevisiae or to the pathogenic yeast Candida albicans. Still, several research groups have started to identify the actors of C. glabrata iron homeostasis and its transcriptional and post-transcriptional regulation. These studies have revealed interesting particularities of C. glabrata and have shed new light on the evolution of fungal iron homeostasis.
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