Journal
MEDICINAL RESEARCH REVIEWS
Volume 40, Issue 1, Pages 413-430Publisher
WILEY
DOI: 10.1002/med.21575
Keywords
breast cancer; ERG; ETS; Ewing sarcoma; leukemia; prostate cancer; small molecule inhibitor
Categories
Funding
- Terry Fox Research Institute
- Terry Fox New Frontiers Program Project Grant
Ask authors/readers for more resources
The ETS family of proteins consists of 28 transcription factors, many of which have been implicated in development and progression of a variety of cancers. While one family member, ERG, has been rigorously studied in the context of prostate cancer where it plays a critical role, other ETS factors keep emerging as potential hallmark oncodrivers. In recent years, numerous studies have reported initial discoveries of small molecule inhibitors of ETS proteins and opened novel avenues for ETS-directed cancer therapies. This review summarizes the state of the art data on therapeutic targeting of ETS family members and highlights the corresponding drug discovery strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available