Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 97, Issue -, Pages 23-30Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.11.076
Keywords
Drug delivery systems; pH and temperature responsive; Magnetic particles; Controlled release
Categories
Funding
- Thailand Research Fund (TRF)-Office of the Higher Education Commission-Kasetsart University [RSA6080046]
- Department of Physics, Faculty of Science, Kasetsart University
- National Nanotechnology Center, Thailand
- King Mongkut's University of Technology Thonburi through the KMUTT 55th Anniversary Commemorative Fund
- Research Program of Toxic Substance Management in the Mining Industry
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In this study, a drug delivery system for chemo-hyperthermia applications is proposed and fabricated. The delivery system consists of magnetic-silica (MagSi) particles being encapsulated within a pH/thermo-responsive chitosan-g-N-isopropylacrylamide (Chi-g-NIPAAm) polymer matrix. The as-prepared MagSi@Chi-g-NIPAArn particles exhibit superparamagnetic behavior with a saturation magnetization (Ms) of 20.14 emu/g. In addition, the MagSi@Chi-g-NIPAAm particles can act as a heat source when subject to an alternating magnetic field (AMF) and have a specific absorptions rate (SAR) of 8.36 Wg(-1). The release of the drug DOX from the synthesized particles is sensitive to both the pH and temperature of its environment. We have compared the drug release when the solution is externally heated up and when it is heated up by the AMF (internal heating). For external heating (when the pH/temperature is 4.0/45 degrees C), 83.30 +/- 2.92% of the DOX were released within the first 5 h. The release of the DOX by the particles in pH 7.4 (temperature of 37 degrees C) was much slower (around 25.87 +/- 1.30% after 25 h). The release of the DOX was much higher (under an acidic condition pH = 4.0) around 57.13 +/- 2.36% within 1 h in the presence of AMF heating. The in vitro cytotoxicity tests of the of DOX-loaded MagSi@Chi-g-NIPAArn particles towards HeLa cancer cells. In general, the toxicities of the drug DOX as part of a MagSi@Chi-g-NIPAAm particles were less than those of the standalone DOX until the concentration of DOX-loaded particles reached 250 mu g/mL, after which the toxicity of DOX in both forms were the same.
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