Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 98, Issue -, Pages 960-968Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.01.068
Keywords
Gold nanoparticles; Silica; Cancer; Poly-2-ethyl-2-oxazoline; beta-Cyclodextrin
Categories
Funding
- FEDER funds through the POCI COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development, and innovation [POCI-01-0145-FEDER-007491]
- National Funds by FCT - Foundation for Science and Technology [UID/Multi/00709/2013]
- FCT [SFRH/BD/109482/2015]
- [CENTRO-01-0145FEDER-028989]
- [POCI-01-0145-FEDER-031462]
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Cancer is one of the major world public health problems and the currently available treatments are nonspecific and ineffective. This reality highlights the importance of developing novel therapeutic approaches. In this field, multifunctional nanomedicines have the potential to revolutionize the currently available treatments. These unique nanodevices can simultaneously act as therapeutic and imaging agents allowing the real-time monitoring of the nanoparticles biodistribution and the treatment outcome. Among the different nanoparticles, the gold-core silica shell (AuMSS) nanoparticles advantageous physicochemical and biological properties make them promising nanoplatforms for cancer therapy. Nevertheless, their successful application as an effective cancer nanomedicine is limited by the unfavorable pharmacokinetics and uncontrolled release of the therapeutic payloads. Herein, a new polymeric coating for AuMSS nanospheres was developed by combining different ratios (25/75, 50/50 and 75/25) of two materials, Poly-2-ethyl-2-oxazoline (PEOZ) and beta-cyclodextrin (beta-CD). The surface functionalization of AuMSS nanospheres led to a size increase and to the neutralization of the surface charge. On the other side, the nanoparticles biological performance was improved. The coated AuMSS nano spheres showed an increased cytocompatibility and internalization rate by the HeLa cancer cells. Overall, the obtained data confirm the successful modification of the AuMSS nanospheres with PEOZ and beta-CD as well as their promising properties for being applied in cancer therapy.
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