Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 97, Issue -, Pages 336-346Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.12.044
Keywords
Calcium phosphate; Tissue engineering; Scaffold; Biodegradation
Categories
Funding
- European Cooperation in Science and Technology (COST)
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Scaffolds for bone tissue engineering require a combination of bioactivity and bioresorption at the sample surface and high mechanical properties in the bulk. This work presents a novel calcium phosphate (CaP)/polycaprolactone (PCL) scaffold with graded composition and porosity fraction. The scaffold is made of (i) a dense hydroxyapatite (HA)beta-tricalcium phosphate (beta-TCP) core, (ii) a macroporous HA/beta-TCP transition layer and (iii) a macroporous PCLAHA/beta-TCP) external layer. The ceramic layers were fabricated by gel-casting whereas the outer composite layer was obtained by a solvent casting/particle leaching process. The microstructure, phase composition and biodegradation of the scaffolds were characterized. The gradient of porosity was clearly obtained whereas the gradation of phase composition was less pronounced. An in vitro dissolution test was performed by immersing the scaffolds in a TRIS solution. The results showed a dissolution phenomenon with possible differentiated mechanisms in the different layers, in relation with the targeted multi-functionality.
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