Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 97, Issue -, Pages 78-83Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.11.079
Keywords
Ionic liquid; PLGA; Drug delivery system; Antibacterial activity; Electron microscopy; NEXAFS
Categories
Funding
- JSPS KAKENHI [JP15K18849, JP17KK0178, JP18K18388]
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Ionic liquids (Ms) containing imidazolium cations have a number of useful properties, such as high permeability to cells, high antimicrobial activity, and good biocompatibility. With the aid of ILs, transdermal delivery, solubilization of poorly soluble drugs were developed and therapeutic effects were improved. In this work, 1-butyl.3-methylimidazolium hexafluorophosphate-incorporated, chitosan-modified, submicron-sized poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared using the emulsion solvent diffusion method for the treatment of biofilm infections. Prepared IL-incorporated PLGA NPs using surfactants such as Tween-80 and poloxamer-188 showed a high antibacterial activity to the bacterial cells under the biofilm. Additionally, antibacterial mechanism of IL-incorporated PLGA NPs was revealed by annular dark field scanning transmission electron microscopy combined a simple sample pretreatment method. We established a drug delivery system using IL-incorporated PLGA NPs to enhance the potential of polymeric nanocarriers for treating biofilm infections.
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