Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 98, Issue -, Pages 503-514Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.12.135
Keywords
Electrospinning; Gymnema sylvestre leaf extracts; Nanofiber; Gymnemagenin; Wound dressing
Categories
Funding
- UGC-DAE Consortium for Scientific Research Kalpakkam, Tamilnadu, India [CSR-KN/CRS-70/2015-16/811]
- Translational and Clinical Research Flagship Program of the Singapore National Research Foundation [NMRC/TCR/008-SERI/2013]
- Co-operative Basic Research Grant from the Singapore National Medical Research Council [NMRC/CBRG/0048/2013]
- SNEC Ophthalmic Technologies Incubator Program grant [R1181/83/2014]
- Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Start-Up Grant [L0412290]
- Strategic Academic Initiative Grant [SAI-L0494003]
- Ministry of Education - Singapore under its Singapore Ministry of Education Academic (AcRF) Research Fund Tier I [2015-T1-001-082]
- Industry Alignment Fund Pre-Positioning Grant [IAF-PP H17/01/a0/0K9]
Ask authors/readers for more resources
Wound care management presents one of the substantial and tenacious challenges to the healthcare systems worldwide. Microbial colonization and subsequent biofilm formation after injury have garnered much attention, as there is an appreciable correlation between biofilms formation and delayed healing in chronic wounds. Nanotechnology has emerged as a potential platform for the management of treating acute and chronic wounds. This study presents the utility of electrospun nanofiber mats containing a natural extract (Gymnema sylvestre) that averts biofilm formation but supports human dermal fibroblasts (hDFs) attachment. The scaffolds exhibited good wettability, enhanced mechanical properties and contact mediated inhibition of Gram-positive and Gram-negative bacteria. MTS viability assay and confocal imaging further confirmed that the natural extract loaded mats remained non-cytotoxic for hDFs. Overall these findings evidenced the suitability of the Gymnema sylvestre (GS) functionalized electrospun poly-epsilon-caprolactone (PCL) nanofibers, as an effective wound dressing with broad spectrum anti-bacterial properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available