Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 230, Issue -, Pages 83-92Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2019.03.047
Keywords
Implant; Additive manufacturing; X-ray tomography; Small X-ray angle scattering; Nano X-ray Laue diffraction mapping
Categories
Funding
- Ministry of Science and Technology Programs [104-2628-E-009-003-MY3, 106-2811-E-009-032, 106-2218-E-007-019, 106-2514-S-007-004, 106-3011-F-002-002, 107-3017-F-009-002, 107-3011-F-002-002, 107-2628-E-009-001-MY3, 107-2218-E-009-003]
- ITRI Programs [F301AR7Z50, G301AR7Z50, GM5400J000TNL]
- Chang Gung Memorial Hospital [CMRPG6D0171-172]
- ITRI Program [F301AR5F20]
- Center for Semiconductor Technology Research from The Featured Areas Research Center Program [107W302]
- [MOST107-2628-E-009-001-MY3]
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Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti-6Al-4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti-6Al-4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti-6Al-4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti-6Al-4V pores enhance the collagen-regulated mineralization.
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