Journal
MARINE DRUGS
Volume 17, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/md17050292
Keywords
marine fungus; Penicillium sp; ZZ380; penicipyrroether A; pyrrospirone J; antiproliferative and antibacterial activities
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Funding
- National Key R&D Program of China [2017YFE0102200]
- National Natural Science Foundation of China [81773587, 81773769]
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The marine-sourced fungus Penicillium sp. ZZ380 was previously reported to have the ability to produce a series of new pyrrospirone alkaloids. Further investigation on this strain resulted in the isolation and identification of novel penicipyrroether A and pyrrospirone J. Each of them represents the first example of its structural type, with a unique 6/5/6/5 polycyclic fusion that is different from the 6/5/6/6 fused ring system for the reported pyrrospirones. Their structures were elucidated by extensive nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic analyses, electronic circular dichroism (ECD) and C-13 NMR calculations and X-ray single crystal diffraction. Penicipyrroether A showed potent antiproliferative activity against human glioma U87MG and U251 cells with half maximal inhibitory concentration (IC50) values of 1.64-5.50 M and antibacterial inhibitory activity with minimum inhibitory concentration (MIC) values of 1.7 g/mL against methicillin-resistant Staphylococcus aureus and 3.0 g/mL against Escherichia coli.
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