Related references
Note: Only part of the references are listed.Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets
Kathryn H. Ching et al.
MABS (2018)
Next generation antibody drugs: pursuit of the 'high-hanging fruit'
Paul J. Carter et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Current progress in innovative engineered antibodies
William R. Strohl
PROTEIN & CELL (2018)
A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library
Adam S. Adler et al.
MABS (2018)
Functional interrogation and mining of natively paired human VH: VL antibody repertoires
Bo Wang et al.
NATURE BIOTECHNOLOGY (2018)
Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles
David F. Tucker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations
Jun Gong et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor
Jennifer D. Koenitzer et al.
MABS (2017)
Epitope mapping reveals the binding mechanism of a functional antibody cross-reactive to both human and murine programmed death 1
Dong Li et al.
MABS (2017)
Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics
Adam S. Adler et al.
MABS (2017)
Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics
Adam S. Adler et al.
MABS (2017)
Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
Devin Sok et al.
NATURE (2017)
An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
Shuguang Tan et al.
NATURE COMMUNICATIONS (2017)
Translational Pharmacokinetic/Pharmacodynamic Modeling of Tumor Growth Inhibition Supports Dose-Range Selection of the Anti-PD-1 Antibody Pembrolizumab
A. Lindauer et al.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2017)
Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms
Yasmina Noubia Abdiche et al.
MABS (2016)
Phage display-derived human antibodies in clinical development and therapy
Andre Frenzel et al.
MABS (2016)
Nivolumab, anti-programmed death-1 (PD-1) monoclonal antibody immunotherapy: Role in advanced cancers
Arun Rajan et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)
Pembrolizumab (Keytruda)
Gerry Kwok et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)
Phase I Study of Pembrolizumab (MK-3475; Anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors
Amita Patnaik et al.
CLINICAL CANCER RESEARCH (2015)
Developability Assessment During the Selection of Novel Therapeutic Antibodies
Alexander Jarasch et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Tree of Life Reveals Clock-Like Speciation and Diversification
S. Blair Hedges et al.
MOLECULAR BIOLOGY AND EVOLUTION (2015)
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Sue Townsend et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1
Krzysztof M. Zak et al.
STRUCTURE (2015)
In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
Brandon J. DeKosky et al.
NATURE MEDICINE (2015)
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
Anthony P. West et al.
CELL (2014)
A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies
Samin Akbari et al.
LAB ON A CHIP (2014)
Diversity of the Antibody Response to Tetanus Toxoid: Comparison of Hybridoma Library to Phage Display Library
Mahsa Sorouri et al.
PLOS ONE (2014)
Comparative analysis of human and mouse immunoglobulin variable heavy regions from IMGT/LIGM-DB with IMGT/HighV-QUEST
Bin Shi et al.
THEORETICAL BIOLOGY AND MEDICAL MODELLING (2014)
Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression
Andrew Buchanan et al.
MABS (2013)
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
Taku Okazaki et al.
NATURE IMMUNOLOGY (2013)
The structural basis of antibody-antigen recognition
Inbal Sela-Culang et al.
FRONTIERS IN IMMUNOLOGY (2013)
Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
Leeying Wu et al.
JOURNAL OF IMMUNOLOGY (2012)
The blockade of immune checkpoints in cancer immunotherapy
Drew M. Pardoll
NATURE REVIEWS CANCER (2012)
Capturing the Natural Diversity of the Human Antibody Response against Vaccinia Virus
Johan Lantto et al.
JOURNAL OF VIROLOGY (2011)
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
Fabian Sievers et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
Klaus Koefoed et al.
MABS (2011)
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
David Yin-Wei Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Fc receptor but not complement binding is important in antibody protection against HIV
Ann J. Hessell et al.
NATURE (2007)
Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing
PJ Meijer et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development
MJH Ratcliffe
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2006)
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
LW Hillier et al.
NATURE (2004)
Humanization of a chicken anti-IL-12 monoclonal antibody
N Tsurushita et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2004)
Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
M Zemlin et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1
M Hezareh et al.
JOURNAL OF VIROLOGY (2001)
Methods for the generation of chicken monoclonal antibody fragments by phage display
J Andris-Widhopf et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2000)