Journal
LIFE SCIENCES
Volume 233, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2019.04.066
Keywords
lncRNA; circRNA; miRNA; Cardiovascular disease
Funding
- National Natural Science Foundation of China [81570250]
- National Clinical Key Specialty Project
- National Key Research and Development Program of China [2016 YFC 1301100]
- Department of Science and Technology of Jilin Province [201603059YY]
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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Non-coding RNAs including long noncoding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) have been reported to participate in pathological developments of CVDs through various mechanisms. Among them, the networks among lncRNAs/circRNAs, miRNAs, and mRNAs have recently attracted attention. Understanding the molecular mechanism could aid the discovery of therapeutic targets or strategies in CVDs including atherosclerosis, myocardial infarction (MI), hypertrophy, heart failure (HF) and cardiomyopathy. In this review, we summarize the latest research involving the lncRNA/circRNA-miRNA-mRNA axis in CVDs, with emphasis on the molecular mechanism.
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