4.6 Article

Biological Macrocycle: Supramolecular Hydrophobic Guest Transport System Based on Nanodiscs with Photodynamic Activity

Journal

LANGMUIR
Volume 35, Issue 24, Pages 7824-7829

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.9b00126

Keywords

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Funding

  1. Thousand Talents Program of China
  2. Postdoctoral Innovative Talents Supporting Project of China [BX20180255]
  3. China Postdoctoral Science Foundation [2017M623231]
  4. Key R&D Program of Shaanxi Province [2019KW-031, 2019KW-038]
  5. Fundamental Research Funds for the Central Universities [3102018zy051, 3102018jcc007, 31020170QD044, 31020170QD045, 3102017OQD040, 3102017OQD115, 3102019ghxm005]
  6. Natural Science Basic Research Plan in Shaanxi Province of China [2018JQ2017]
  7. National Nature Science Foundation of China [21673056]
  8. State Key Laboratory of Solidification Processing in NPU [SKLSP201817]
  9. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety [NSKF201801]

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A biogenic macrocycle-based guest loading system has been developed by the self-assembly of membrane scaffold protein and phospholipids. The resulting 10 nm level transport system can increase the solubility of hydrophobic photodynamic agent hypocrellin B in aqueous medium and exhibited a cellular internalization capacity with substantial photodynamic activity.

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