Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 20, Issue 6, Pages 488-495Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1900039
Keywords
Exosome; Long non-coding RNA (lncRNA); Biosynthesis; Biomarker; Drug resistance
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Funding
- National Natural Science Foundation of China [81672791, 81872300]
- Foundation of the Department of Education of Zhejiang Province, China [Y201224954]
- Zhejiang Provincial Natural Science Foundation of China [LY14H040007]
- Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China [LR18C060002]
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Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
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