Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 20, Issue 5, Pages 428-436Publisher
ZHEJIANG UNIV PRESS
DOI: 10.1631/jzus.B1900155
Keywords
Hyaluronic acid; Extracellular matrix; Cardiovascular vessel; Heart; Brain
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Funding
- Key Research and Development Program of the Ministry of Science and Technology [2017YFC0111902]
- Shanghai Natural Science Foundation, China [13ZR1404700]
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Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.
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