Journal
JOURNAL OF VIROLOGY
Volume 93, Issue 13, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00238-19
Keywords
B-cell lymphomas; Epstein-Barr virus; lymphoblastoid cell lines; tumor virology
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Funding
- Wellcome Trust/DBT India Alliance Intermediate Fellowship research grant [IA/I/14/2/501537]
- National Institutes of Health [P01CA174439, R01177423, R01171979, P30DK050306, P30CA016520, U54CA190158]
- Avon Foundation for Women
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Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis.
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