Journal
BIOMACROMOLECULES
Volume 16, Issue 12, Pages 3740-3750Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b00940
Keywords
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Funding
- NIH training fellowship [T32 HL076122]
- College of Engineering and Mathematical Sciences at University of Vermont
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beta-Cyclodextrin (beta-CD), with a lipophilic inner cavity and hydrophilic outer surface, interacts with a large variety of nonpolar guest molecules to form noncovalent inclusion complexes. Conjugation of beta-CD onto biomacromolecules can form physically cross-linked hydrogel networks upon miming with a guest molecule. Herein, the development and characterization of self-healing, thermoresponsive hydrogels, based on host guest inclusion complexes between alginate-graft-beta-CD and Pluronic F108 (poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)), are described. The mechanics, flow characteristics, and thermal response were contingent on the polymer concentration and the host guest molar ratio. Transient and reversible physical cross-linking between host and guest polymers governed self-assembly, allowing flow to occur under shear stress and facilitating complete recovery of the material's properties within a few seconds of unloading. The mechanical properties of the dual-cross-linked, multi-stimuli-responsive hydrogels were tuned as high as 30 kPa at body temperature and are advantageous for biomedical applications such as drug delivery and cell transplantation.
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