Journal
NUTRITION IN PREVENTION AND MANAGEMENT OF DEMENTIA
Volume 1367, Issue -, Pages 31-37Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.13047
Keywords
diet patterns; dementia; Alzheimer's disease; cognitive decline
Categories
Funding
- NCRR NIH HHS [P41 RR008630] Funding Source: Medline
- NIA NIH HHS [R01 AG031553] Funding Source: Medline
- NIEHS NIH HHS [R21 ES021290] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR008630] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R21ES021290] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG031553] Funding Source: NIH RePORTER
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After two decades of research on nutrition and dementia there is strong evidence for preventive effects of vitamin E, B vitamins, and n-3 fatty acids and deleterious effects of saturated fat on dementia. Among specific foods with evidence of neuroprotection are green leafy vegetables, other vegetables, berries, and seafood. A number of studies have examined dietary patterns, particularly the Mediterranean diet and DASH (Dietary Approaches to Stop Hypertension), neither of which is tailored to the specific foods and nutrients that have been identified as neuroprotective. A new diet called MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) incorporates many elements of the Mediterranean diet and DASH but with modifications that reflect current evidence for brain neuroprotection. The evidence in support of the relation of various nutrients and the Mediterranean diet to dementia has been inconsistent. The inconsistencies may be explained by inattention to nutrient/food intake levels in the interpretation of study findings and trial design, including a shifting metric among studies for scoring adherence to the Mediterranean diet. Future studies should pay particular attention to levels of intake in the design and analyses of nutritional studies.
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