Journal
MUSCULOSKELETAL REPAIR AND REGENERATION
Volume 1383, Issue -, Pages 5-20Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.13191
Keywords
progranulin; TNFR; arthritis; bone regeneration
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Funding
- NIH [R01AR062207, R01AR061484]
- Disease Targeted Research Grant from Rheumatology Research Foundation
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR062207] Funding Source: NIH RePORTER
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Progranulin (PGRN) is a growth factor with a unique beads-on-a-string structure that is involved in multiple pathophysiological processes, including anti-inflammation, tissue repair, wound healing, neurodegenerative diseases, and tumorigenesis. This review presents up-to-date information concerning recent studies on the role of PGRN in inflammatory arthritis and osteoarthritis, with a special focus on the involvement of the interactions and interplay between PGRN and tumor necrosis factor receptor (TNFR) family members in regulating such musculoskeletal diseases. In addition, this paper highlights the applications of atsttrin, an engineered protein comprising three TNFR-binding fragments of PGRN, as a promising intervention in treating arthritis.
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