Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 17, Pages 6853-6858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b03024
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Funding
- NIHGMS [R01 GM093213]
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Copper oxidative addition into organo-halides is a challenging two-electron process. In contrast, formal oxidative addition of copper to C-sp(2), carbon- bromine bonds can be accomplished by employing latent silyl radicals under photoredox conditions. This novel paradigm for copper oxidative addition has now been applied to a Cu-catalyzed cross-coupling of C-sp(3)-bromides. Specifically, a copper/photoredox dual catalytic system for the coupling of alkyl bromides with trifluoromethyl groups is presented. This operationally simple and robust protocol successfully converts a variety of alkyl, allyl, benzyl, and heterobenzyl bromides into the corresponding alkyl trifluoromethanes.
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