Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 15, Pages 6122-6126Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b10904
Keywords
-
Categories
Funding
- Australian Research Council
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
- Australian National Fabrication Facility at the University of Queensland
- Australia Research Training Program (RTP) Scholarship
- Advance Queensland Research Fellowship
Ask authors/readers for more resources
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure-function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available