Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 152, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.supflu.2019.104547
Keywords
Mefenamic acid; Polymorphism; Conformational manifold; Supercritical fluid technologies; IR spectroscopy; Raman spectroscopy
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Funding
- Russian Foundation for Basic Research [17-03-00459, 18-29-06008]
- French Embassy in Russia (Metchnikov program 2018) [915125G]
- Ministry of Education and Science of the Russian Federation [01201260481]
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In this paper we have studied the conformations of mefenamic acid molecules in its saturated solution in supercritical carbon dioxide being in contact with bottom phase containing different polymorphs of mefenamic acid under isochoric heating conditions in the temperature range of 80-220 degrees C. For this purpose, we used in situ IR and Raman spectroscopy as well as micro IR and micro Raman spectroscopy and quantum chemical calculations. We have found that there is a correlation between the polymorphic modifications of the crystalline form of mefenamic acid and its conformers in CO2 fluid phase. The results of this work have shown that it is possible to monitor the polymorphic transformation of the crystalline phase of mefenamic acid by screening its molecular conformations in a fluid solution. This finding opens up the possibilities to manage the obtaining of certain polymorph of mefenamic acid with high purity degree from its fluid solution by means of variation of thermodynamic parameters of this solution. (C) 2019 Elsevier B.V. All rights reserved.
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