Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 112, Issue -, Pages 89-98Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2019.02.023
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Funding
- New South Wales Health, Neurobehavioural Genomics Unit grant
- National Health and Medical Research Council (NHMRC) [1067137, 1147644]
- Australian NHMRC
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
- Schizophrenia Research Institute (Australia)
- Macquarie Group Foundation
- University of Newcastle RHD Scholarship
- University of Newcastle
- Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship
- NHMRC Senior Research Fellowship [1121474]
- NSW Health
- National Health and Medical Research Council of Australia [1067137, 1147644] Funding Source: NHMRC
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The aetiology of schizophrenia is complex, heterogeneous, and involves interplay of many genetic and environmental influences. While significant progress has been made in the understanding the common heritable component, we are still grappling with the genomic encoding of environmental risk. One class of molecule that has tremendous potential is miRNA. These molecules are regulated by genetic and environmental factors associated with schizophrenia and have a very significant impact on temporospatial patterns of gene expression. To better understand the relationship between miRNA and gene expression in the disorder we analysed these molecules in RNA isolated from peripheral blood mononuclear cells (PBMCs) obtained from an Australian cohort of 36 individuals with schizophrenia and 15 healthy controls using next-generation RNA sequencing. Significant changes in both mRNA and miRNA expression profiles were observed implicating important interaction networks involved in immune activity and development. We also observed sexual dimorphism, particularly in relation to variation in mRNA, with males showing significantly more differentially expressed genes. Interestingly, while we explored expression in lymphocytes, the systems biology of miRNA-mRNA interactions was suggestive of significant pleiotropy with enrichment of networks related to neuronal activity.
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