Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 140, Issue 1, Pages 106-108Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2019.03.007
Keywords
Anesthesia; Anxiety response; Rodent model
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Funding
- MSD Life Science Foundation
- Uehara Memorial Foundation
- Suzuken Memorial Foundation
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We investigated the effects of variations in anesthesia exposure time prior to conducting anxiety response behavioral testing in sham controls from an experimental murine model. The staying time in the center area of the Open Field test in the long exposure group was significantly decreased compared to that of the short exposure group. Significant correlation was found between anesthesia time and the duration of staying time in the center area. We conclude that anesthesia time may have a significant impact on behavioral anxiety testing in this context, and advise careful control of this parameter in protocol optimization in related surgical animal models. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
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