Journal
JOURNAL OF PERINATOLOGY
Volume 39, Issue 6, Pages 784-790Publisher
SPRINGERNATURE
DOI: 10.1038/s41372-019-0370-5
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Funding
- National Health and Medical Research Council of Australia [1041835, 1108365]
- Bill and Melinda Gates Foundation
- Victorian State Government Operational Infrastructure Scheme
- National Health and Medical Research Council of Australia [1108365] Funding Source: NHMRC
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Objective To investigate a potential new marker for the prediction of small for gestational age (SGA) infants. Study design Nested case-control study involving 280 uncomplicated pregnancies and 70 cases of SGA without pre-eclampsia. Serum podocalyxin was measured at 11-13 weeks of gestation and results were expressed in multiples of the median (MoM). The performance of screening by a combination of maternal history and podocalyxin levels was assessed with ROC curves. Results SGA was predicted by maternal age, height, South Asian ethnicity, and previous delivery without pre-eclampsia. Median podocalyxin levels were higher in affected than uncomplicated pregnancies (1.303 versus 0.994 MoM, p < 0.001). At a 10% false-positive rate, maternal history identified 40.0% of the cases (AUC=0.74, 95% CI 0.671-0.809). The addition of podocalyxin increased the detection to 54.3% (AUC=0.78, 95% CI 0.771-0.842, p=0.027 for the difference in ROC curves). Conclusion First-trimester podocalyxin may be useful in screening for SGA infants.
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