Journal
JOURNAL OF PEDIATRIC SURGERY
Volume 54, Issue 11, Pages 2382-2386Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jpedsurg.2019.04.023
Keywords
Pediatric liver transplantation; Low-body-weight donor; Hepatic artery thrombosis; Small-for-size syndrome
Categories
Funding
- Tianjin Clinical Research Center for Organ Transplantation Project [15ZXLCSY00070]
- Key Project of Tianjin Health and Family Planning Commission [16KG107]
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Background: Donors with low-body-weight were previously reported to be related to inferior recipient outcomes in pediatric liver transplantation. However, the scarce availability of age and size-matched organs has encouraged us to re-evaluate the feasibility and safety of using low-body-weight donors. Methods: We retrospectively analyzed 91 deceased donor pediatric liver transplantation between January 2014 and December 2016, donor weight less than 5 kg was defined as low-body-weight donors. The recipients were divided into two groups according to donor weight. (<= 5 kg and 5 kg < to <= 20 kg). Donor and recipient characteristics, perioperative data, postoperative complications as well as graft and recipient survival rate were compared Results: The recipients and grafts recovery after transplantation were comparable between two groups. The recipients receiving low-body-weight donors showed higher risk of hepatic artery thrombosis and small-for-size syndrome, however, these complications can effectively be treated by our strategies. The 2-year patient survival rates were 92.9% and 95.2%, 2-year graft survival rates were 92.9% and 93.7% in Groups 1 and 2, without significant difference. Conclusions: Our finding suggested that the utility of livers from low-body-weight donors is a potential strategy to increase donor availability in well-selected pediatric recipients. (C) 2019 Elsevier Inc. All rights reserved.
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