Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 9, Pages 5773-5782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00765
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Funding
- Natural Science Foundation of China [21772176, 21372201]
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A facile method for the synthesis of 3-iodoimidazo[1,2-a]pyridines has been successfully developed involving an I2O5-mediated iodocyclization cascade of N-(1-arylallyl)pyridin-2-amines with concomitant C=C bond cleavage. Preliminary mechanistic studies reveal that this protocol might undergo an oxidative cyclization/decarboxylation/iodination sequence in which I2O5 is used as both an oxidant and an iodine source. The present protocol has advantages of wide substrate scope, simple operation, and metal-free conditions.
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