Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 6, Pages 1550-1557Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00042
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Funding
- National Natural Science Foundation [21532007]
- Institute of Drug Innovation, CAS [CASIMM0120181001]
- Biological Resources Programme, CAS [ZSTH-032]
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Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 mu M).
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