Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 5, Pages 1391-1395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00259
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Funding
- National Natural Science Foundation of China [81872781, 81273414, 81302675]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-12M-2-002]
- Drug Innovation Major Project [2018ZX09711001-007-002, 2015ZX09304006-016]
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Raistrickindole A (1), a new indole diketopiperazine alkaloid containing an unusual pyrazino[1',2':2,3]-[1,2]oxazino[6,5-b]indole tetraheterocyclic ring system, a new benzodiazepine derivative, raistrickin (2), and the known haenamindole (3) and sclerotigenin (4) were isolated from the marine-derived fungus Penicillium raistrickii IMB17-034. Their structures were elucidated by extensive spectroscopic analyses and TDDFT calculations of the NMR and ECD data. Compounds 1 and 2 showed inhibitory activities against the hepatitis C virus.
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